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Perspectivas Actuales Sobre la Resistencia Antifúngica: Enfoque en Micosis Oportunistas

By
Natalia Raquel Aguiar Muñoz ,
Natalia Raquel Aguiar Muñoz

Universidad Técnica de Ambato. Facultad de Ciencias de la Salud, Carrera de Laboratorio Clínico. Ambato, Ecuador

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Carlos Fernando Yauli Flores ,
Carlos Fernando Yauli Flores

Universidad Técnica de Ambato. Facultad de Ciencias de la Salud, Carrera de Laboratorio Clínico. Ambato, Ecuador

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Abstract

Introduction: opportunistic mycoses, caused by fungi in individuals with compromised immune systems, are on the rise, posing significant challenges in healthcare. This article reviews antifungal resistance with the aim of highlighting its increasing incidence and the need for new therapeutic strategies and precise diagnostic methods. The necessity for standardized laboratory protocols and the implementation of sensitive techniques for early detection and optimal treatment is emphasized.
Methods: a systematic review was conducted using PubMed, Scopus, and Google Scholar; search terms and Boolean operators such as "(Opportunistic Mycoses) AND (Antifungal Resistance)" and "(Antifungals) AND (Resistance Genes)" were used. Additionally, the guidelines established by the PRISMA statement were followed, and the PICO approach was employed.
Results: twelve studies were evaluated; 58,33 % (n=7) assessed antifungal resistance, while 41,67 % (n=5) addressed aspects such as mechanisms of action and genetics. 66 % of the studies evaluated resistance in Candida spp., while 16,7 % analyzed resistance in Aspergillus spp., making them the most studied pathogens. Various resistance genes were evaluated in all studies; moreover, fluconazole was found to be the most studied antifungal, followed by amphotericin B and voriconazole.
Conclusion: early identification of antifungal resistance, the development of new therapies, and the standardization of diagnostic methods are essential to mitigate its impact on public health.

How to Cite

1.
Aguiar Muñoz NR, Yauli Flores CF. Perspectivas Actuales Sobre la Resistencia Antifúngica: Enfoque en Micosis Oportunistas. Salud, Ciencia y Tecnología [Internet]. 2024 Jun. 14 [cited 2024 Jul. 15];4:1064. Available from: https://revista.saludcyt.ar/ojs/index.php/sct/article/view/1064

The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.

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