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Evidence for carbetocin in obstetric hemorrhage

By
Edison Andrés Tixe Lluglla ,
Edison Andrés Tixe Lluglla

Hospital General Latacunga, Latacunga, Ecuador

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María Carolina Chalan Analuisa ,
María Carolina Chalan Analuisa

Hospital General Latacunga, Latacunga, Ecuador

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Inés Paulina Panimboza Guamán ,
Inés Paulina Panimboza Guamán

Hospital General Latacunga, Latacunga, Ecuador

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Jhon Michael Sanaguano Castillo ,
Jhon Michael Sanaguano Castillo

Investigador independiente, Médico. Ecuador

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Pablo Rodrigo Escobar Castillo ,
Pablo Rodrigo Escobar Castillo

Centro de Salud Guayusa, Médico. Ecuador

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Fernanda Gabriela Dután Ortiz ,
Fernanda Gabriela Dután Ortiz

Centro de Salud tipo “C” La Troncal, Médico. Ecuador

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Paola Elizabeth Serpa Román ,
Paola Elizabeth Serpa Román

Hospital del Día la Troncal (IESS) Médico. Ecuador

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Michelle Estefanía Quispe Punina ,
Michelle Estefanía Quispe Punina

Centro de salud 10 de agosto, Médico. Ecuador

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Abstract

Introduction: A common procedure is to administer uterotonic agents regularly for the prophylaxis of postpartum and post-cesarean hemorrhage. The typical uterotonic drug recommended for this use is oxytocin, however, literature indicates better beneficial effects with carbetocin due to its sustained and prolonged uterotonic activity, as well as its safety and good tolerability.
Objective: To outline the data on carbetocin that has been found so far in relation to obstetric hemorrhage.
Methods: For this literature review, keywords related to carbetocin and obstetric hemorrhage were located using health sciences descriptors, and then searched in databases and search engines such as Google Scholar, PubMed, Lilacs, SciELO, Cochrane, and PubMed. Out of a total of 100 bibliographies, 32 articles were considered.
Results: Carbetocin is a thermally stable drug with a half-life approximately 4-10 times longer than oxytocin, with sustained uterotonic activity with the administration of a single dose (100 μg) intravenously or intramuscularly.
Conclusions: Carbetocin is a safe drug for prescription in patients with specific pathologies, as it maintains prolonged uterotonic effect, useful in post-cesarean hemorrhages. Its use is not yet fully promoted due to the high cost it represents at present.

How to Cite

1.
Tixe Lluglla EA, Chalan Analuisa MC, Panimboza Guamán IP, Sanaguano Castillo JM, Escobar Castillo PR, Dután Ortiz FG, Serpa Román PE, Quispe Punina ME. Evidence for carbetocin in obstetric hemorrhage. Salud, Ciencia y Tecnología [Internet]. 2023 Mar. 26 [cited 2024 Jul. 20];3:341. Available from: https://revista.saludcyt.ar/ojs/index.php/sct/article/view/341

The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.

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