Evidencia de la carbetocina en la hemorragia obstétrica

Edison Andrés Tixe Lluglla; María Carolina Chalan Analuisa; Inés Paulina Panimboza Guamán; Jhon Michael Sanaguano Castillo; Pablo Rodrigo Escobar Castillo; Fernanda Gabriela Dután Ortiz; Paola Elizabeth Serpa Román; Michelle Estefanía Quispe Punina

doi:10.56294/saludcyt2023341

Review

Published: 2023-03-26

DOI: https://doi.org/10.56294/saludcyt2023341

Evidence for carbetocin in obstetric hemorrhage

Abstract

Introduction: A common procedure is to administer uterotonic agents regularly for the prophylaxis of postpartum and post-cesarean hemorrhage. The typical uterotonic drug recommended for this use is oxytocin, however, literature indicates better beneficial effects with carbetocin due to its sustained and prolonged uterotonic activity, as well as its safety and good tolerability.
Objective: To outline the data on carbetocin that has been found so far in relation to obstetric hemorrhage.
Methods: For this literature review, keywords related to carbetocin and obstetric hemorrhage were located using health sciences descriptors, and then searched in databases and search engines such as Google Scholar, PubMed, Lilacs, SciELO, Cochrane, and PubMed. Out of a total of 100 bibliographies, 32 articles were considered.
Results: Carbetocin is a thermally stable drug with a half-life approximately 4-10 times longer than oxytocin, with sustained uterotonic activity with the administration of a single dose (100 μg) intravenously or intramuscularly.
Conclusions: Carbetocin is a safe drug for prescription in patients with specific pathologies, as it maintains prolonged uterotonic effect, useful in post-cesarean hemorrhages. Its use is not yet fully promoted due to the high cost it represents at present.

Keywords:

PPH prevention,

Postpartum hemorrhage,

Carbetocin,

Oxytocin,

How to Cite

Tixe Lluglla EA, Chalan Analuisa MC, Panimboza Guamán IP, Sanaguano Castillo JM, Escobar Castillo PR, Dután Ortiz FG, Serpa Román PE, Quispe Punina ME. Evidence for carbetocin in obstetric hemorrhage. Salud, Ciencia y Tecnología [Internet]. 2023 Mar. 26 [cited 2024 Apr. 19];3:341. Available from: https://revista.saludcyt.ar/ojs/index.php/sct/article/view/341

Copyright Notice

The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.

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