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Biological markers in alcoholic liver disease

By
Shirley Estefania Naranjo Yucailla ,
Shirley Estefania Naranjo Yucailla

Universidad Técnica de Ambato, Facultad de Ciencias de la Salud, Carrera de Laboratorio Clínico. Ambato, Ecuador

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Ana Gabriela Pacha Jara ,
Ana Gabriela Pacha Jara

Universidad Técnica de Ambato, Facultad de Ciencias de la Salud, Carrera de Laboratorio Clínico. Ambato, Ecuador

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Abstract

Alcoholic liver disease is characterized by liver damage caused by long-term excessive alcohol consumption. Alcohol is absorbed in the gastrointestinal tract and primarily metabolized in the liver, where hepatocytes accumulate toxins and experience increased oxidation, resulting in substances that can harm liver tissue. Alcohol metabolism in the liver occurs through three metabolic pathways: the first pathway occurs in the cytoplasm of hepatocytes, the second occurs in the smooth endoplasmic reticulum, and the enzyme catalase mediates the last one. Common alcohol-related liver conditions include simple alcoholic steatosis, alcoholic hepatitis, and cirrhosis. For the study of alcohol-related liver disease, it is recommended to determine biological markers such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), mean corpuscular volume (MCV), and alkaline phosphatase (ALP). Therefore, the development of this literature review is of great importance as it is considered useful to investigate the biomarkers that can be used to detect alcoholic liver disease, considering that alcohol addiction is currently a highly uncontrollable problem worldwide.

How to Cite

1.
Naranjo Yucailla SE, Pacha Jara AG. Biological markers in alcoholic liver disease. Salud, Ciencia y Tecnología [Internet]. 2023 Aug. 22 [cited 2024 Apr. 23];3:469. Available from: https://revista.saludcyt.ar/ojs/index.php/sct/article/view/469

The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.

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