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Assessment of insulin resistance using the HOMA index: a comparative approach between premenopausal and postmenopausal women

By
Carlos Fernando Yauli Flores ,
Carlos Fernando Yauli Flores

Universidad Técnica de Ambato, Facultad de Ciencias de la Salud, Carrera de Laboratorio Clínico. Ambato, Ecuador.

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Ericka Jazmín Tubón Luisa ,
Ericka Jazmín Tubón Luisa

Universidad Técnica de Ambato, Facultad de Ciencias de la Salud, Carrera de Laboratorio Clínico. Ambato, Ecuador.

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Abstract

ABSTRACT

Introduction: Menopause exerts a marked influence on Insulin Resistance. The homeostatic model for assessing insulin resistance (HOMA-IR) is a proven effective and useful clinical tool. The aim of this study was to seek scientific information to understand the differences, underlying factors and relevant implications in the detection of this condition in two stages of women's life. Methods: A systematic review was performed in Google Scholar, Scopus and PubMed using key terms such as Insulin Resistance Assessment, HOMA Index, HOMA-IR, Premenopausal women, Postmenopausal women, Menopause and Comparative Study. The search was limited to English language articles published in the last five years, which were analyzed according to PRISMA methodology. Results: Eight studies were evaluated, 50% focused on postmenopausal women, 25% on premenopausal women and another 25% both stages. The studies showed a higher body mass index in postmenopausal women, associated with 34.2% of insulin resistance in this population. In all studies, HOMA-IR and Body Mass Index (BMI) were evaluated, and 87.5% included lipid profile. In addition, 12.5% suggested innovative metrics such as Triglyceride to Glucose Index (TGI) and Galactin-3 Binding Protein (Gal-3BP) as new biomarkers. Conclusion: Assessment of insulin resistance with HOMA-IR is common, but the results reveal remarkable variations among the stages analyzed. Recognizing hormonal and metabolic differences is essential to improve accuracy and guide preventive strategies in the management of IR.

How to Cite

1.
Yauli Flores CF, Tubón Luisa EJ. Assessment of insulin resistance using the HOMA index: a comparative approach between premenopausal and postmenopausal women. Salud, Ciencia y Tecnología [Internet]. 2024 Feb. 19 [cited 2024 Apr. 23];4:729. Available from: https://revista.saludcyt.ar/ojs/index.php/sct/article/view/729

The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.

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