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Pseudomonas aeruginosa: A Persistent Pathogen and Current Approaches to Treatment- Microbiology

By
Nitish Kumar ,
Nitish Kumar

Jaipur National University, School of Life and Basic Sciences, Jaipur, India

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Vasundhara ,
Vasundhara

Teerthanker Mahaveer University, Department of Microbiology, Moradabad, Uttar Pradesh, India

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Sandeep Kumar Chavan ,
Sandeep Kumar Chavan

Department of Genetics, School of Sciences, JAIN (Deemed-to-be University), Bangalore, India

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Abstract

Pseudomonas aeruginosa (P. aeruginosa) represents an important bacterial pathogen, mainly because it may infect immunocompromised hosts, hospital patients, and people with cystic fibrosis (CF). Antimicrobial resistance has risen due to monitoring nosocomial P. aeruginosa infections, with tendencies toward model drug and carbapenem resistance. Some of the mechanisms of antimicrobial resistance include the downregulation of outer membrane porins, -lactamases, and multidrug efflux pumps. Toxins that be secreted and can build BioFlim (BF) are examples of virulence mechanisms. Effective therapy of infection caused by P. aeruginosa requires early delivery of the appropriate antibiotic medications, source control measures, and, where possible, prevention. Antibacterial de-escalation is supposed to be considered within patients by a positive clinical response, particularly as antibacterial susceptibilities were identified. Less common antibacterials, including Colistin, may be needed to treat multidrug-resistant P. aeruginosa, although additional anti-pseudomonal antibacterials should become accessible soon.

How to Cite

1.
Kumar N, Vasundhara, Kumar Chavan S. Pseudomonas aeruginosa: A Persistent Pathogen and Current Approaches to Treatment- Microbiology. Salud, Ciencia y Tecnología [Internet]. 2023 Jun. 11 [cited 2024 Jul. 20];3:404. Available from: https://revista.saludcyt.ar/ojs/index.php/sct/article/view/404

The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.

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