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Published January 1, 2024

Salud, Ciencia y Tecnología

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Editorial Salud, Ciencia y Tecnología

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Salud, Ciencia y Tecnología

ISSN-L: 2796-9711

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2024-02-23 Original
Evaluación de los requisitos de gestión de los servicios prestados por los laboratorios clínicos privados del Cantón Ambato

By Edison A. Galárraga-Perez, Alejandra E. Moreira-Ramos, Johanna J. Chasi-Tisalema

Introduction: Management requirements are parameters that have been established by international organizations such as the International Organization for Standardization (ISO), which allow clinical laboratories to implement the necessary requirements to achieve the long-awaited quality, through adequate compliance with each one of these parameters.
Objective: To evaluate the degree of compliance with the management requirements of the services provided by the private clinical laboratories of the Ambato Canton. Methods: An observational, descriptive, cross-sectional study with a qualitative approach was designed, through the application of evaluation instruments, surveys with multiple choice questions, 80 interviews were carried out with the directors of private clinical laboratories with current operating permits, different levels of operation, in the Ambato Canton. Results: It was evident that the majority of laboratories meet some of these requirements, however, a minority percentage did not meet them in their entirety. Through a comparative analysis, it was established that 77.90% of the universe studied did have the management requirements implemented, 9.27% partially coupled them or were in the process of implementation, 10.80% did not comply with them and finally 2.03% consider them not applicable in relation to the 15 indicators evaluated. Conclusions: It was determined that, in a high percentage of private clinical laboratories in the Ambato Canton, the quality management requirements of the services provided are implemented, however, a smaller percentage of laboratories do not put these requirements into practice in their establishments.

2024-01-14 Systematic reviews or meta-analyses
Lipidomics: A comprehensive view of the lipid profile and its relationship to cardiovascular risk

By Karen Nicole Punina Lindo, Álvaro Sebastián Ron Mora

Introduction: the World Health Organization stated that cardiovascular diseases cause the death of 17.9 million people annually. The Spanish Society of Arteriosclerosis recommended complete lipid analysis including total cholesterol, HDL cholesterol, triglycerides, LDL cholesterol, apolipoprotein B and lipoprotein (a) for cardiovascular risk.
Objective: to conduct a review article on lipidomics and its integral approach in the analysis of the lipid profile, with emphasis on its relationship with cardiovascular risk, by searching and synthesizing relevant and updated scientific literatura.
Methods: the search was carried out in the databases PubMed, Science Direct, Scopus and in the Google Schoolar search engine, following the PRISMA guidelines, the PICO question was posed, studies from the last 5 years and in English language were included.
Results: A total of 5827 documents were obtained and 11 articles were included in the analysis of results. Six articles were used to determine the relationship between non-HDL cholesterol, LDL cholesterol, apolipoprotein B and remaining cholesterol with cardiovascular risk, three for the relationship between lipoprotein (a) and cardiovascular risk and two were used in relation to ethnicity and formulas to determine lipoproteins.
Conclusions: apolipoprotein B over non-HDL cholesterol and LDL cholesterol is the best lipid biomarker, lipoprotein (a) is recommended to be measured once in life and it is advisable to measure LDL cholesterol directly. Introduction: the World Health Organization stated that cardiovascular diseases cause the death of 17.9 million people annually. The Spanish Society of Arteriosclerosis recommended complete lipid analysis including total cholesterol, HDL cholesterol, triglycerides, LDL cholesterol, apolipoprotein B and lipoprotein (a) for cardiovascular risk.
Objective: to conduct a review article on lipidomics and its integral approach in the analysis of the lipid profile, with emphasis on its relationship with cardiovascular risk, by searching and synthesizing relevant and updated scientific literatura.
Methods: the search was carried out in the databases PubMed, Science Direct, Scopus and in the Google Schoolar search engine, following the PRISMA guidelines, the PICO question was posed, studies from the last 5 years and in English language were included.
Results: A total of 5827 documents were obtained and 11 articles were included in the analysis of results. Six articles were used to determine the relationship between non-HDL cholesterol, LDL cholesterol, apolipoprotein B and remaining cholesterol with cardiovascular risk, three for the relationship between lipoprotein (a) and cardiovascular risk and two were used in relation to ethnicity and formulas to determine lipoproteins.
Conclusions: apolipoprotein B over non-HDL cholesterol and LDL cholesterol is the best lipid biomarker, lipoprotein (a) is recommended to be measured once in life and it is advisable to measure LDL cholesterol directly.

2024-02-16 Review
Emerging biomarkers in gestational diabetes: perspectives for improving diagnosis and prognoses

By Andrea Belén Miranda Sánchez, Álvaro Paul Moina Veloz

Gestational diabetes mellitus is a pathology suffered by one in seven pregnant women worldwide, in which carbohydrate metabolism is altered, that is, glucose intolerance occurs. It is recognized for the first time in pregnancy since these adaptations occur with the objective of providing an adequate amount of glucose to the fetus for its development. They are related to risk factors such as age, diet, lack of physical activity, among others, and can cause fetal macrosomia, neonatal jaundice, and cardiorespiratory complications. In the mother, it is diagnosed through different blood glucose tests such as the oral glucose tolerance test, O'Sullivan test, however currently new biomarkers have been implemented for an early prognosis such as IL-27, a protein retinol transporter 4, maternal fetuin A, high sensitivity C-reactive protein and molecular biomarkers, but more studies are required so that these biochemical markers can be standardized by an organization.

2024-02-18 Short communications
Evidence-based design: a critical success factor for the implementation of Care Management Models

By Javier Rojas-Avila, Katiuska Lídice Reynaldos-Grandón

Introduction: Health institutions are inserted in an organizational conglomerate and where each of the organizations that make up society are subject to management as a fundamental pillar for their permanence in the system. There is an element that in the evidence of the implementation of care management models has not been raised as a critical success factor and that is essential in the organizational structure. This is evidence-based design (EBD). Therefore, the objective of this article is to explain the relevance of DBE in the implementation of care management models.
Development: The design of healthcare facilities is a complex process that not only creates and allocates physical spaces, but also shapes the dynamic flows of patients, staff, visitors, equipment and information. In this context, it is relevant that nurse managers are participants in the prior planning and programming process, so that they are involved in making structural decisions that allow patients' needs to be resolved.
Conclusion: With the current unprecedented increase in hospital construction, it is imperative to integrate the institutional management model, the financing model and the care management model and consider the environmental characteristics that influence the well-being of patients, visitors and personnel are identified and incorporated into future hospital designs.

2024-01-03 Case Report
Gastric trichobezoar in a 4-year-old female patient with surgical resolution. Case report

By Freddy Alexander Aldaz Vallejo, Tatiana del Rosario Pérez Landázuri, Devora Estefania Manzano Quisimalin, Jennifer Carolina Martínez, Estefany Elein Bonilla Ortiz, Jhoselyn Misheel Guerrero Ramos

Introduction: Bezoars are indigestible substances that accumulate in the gastrointestinal tract, most often in the stomach. Gastric Trichobezoar (GT) is the most common bezoar found in the stomach. According to their content, bezoars are divided into plant bezoars, capillary bezoars, lactose bezoars and medicinal bezoars. The most common complications reported over the years include gastric mucosal erosion, gastric or small bowel ulceration and perforation, gastric outlet obstruction, intussusception, obstructive jaundice, protein deficiency enteropathy, pancreatitis, and death. The treatment is surgery.
Clinical case: A 4-year-old female patient presents with cough and odynophagia, accompanied by abdominal pain located in the epigastrium, which persists and is exacerbated by movements, does not radiate, is accompanied by an unquantified rise in temperature, imaging studies are performed where it draws attention. Abdominal echo with report of mass at the level of the epigastrium, abdominal x-ray was performed with evidence of levels. They performed a simple abdominal tomography which confirmed the presence of a foreign body in the stomach classified as a bezoar.
Evolution: Exploratory laparotomy + gastrostomy + trichobezoar extraction + gastric raphia was performed, a procedure without complications. Stable patient, without oxygen support, no signs of respiratory distress, tolerates feeding, better pain control, with good post-surgical evolution.
Conclusions: Trichobezoars are extremely rare and pose diagnostic and treatment problems. Although laparoscopy currently seems to have promising results in expert hands, laparotomy remains the most successful surgical treatment. Postoperative psychological treatment is essential to correct patients' psychological and behavioral alterations and prevent their recurrence.

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