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Clinical and psychological effects post intralesional management with Collagenase Clostridium histolyticum in Peyronie's disease. Bibliographic review

By
Christopher Hilario Acosta Nuñez ,
Christopher Hilario Acosta Nuñez

Universidad Técnica de Ambato, Facultad Ciencias de la Salud, Carrera de Medicina. Ambato, Ecuador

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Estefanía Aracelly Reyes Rosero ,
Estefanía Aracelly Reyes Rosero

Universidad Técnica de Ambato, Facultad Ciencias de la Salud, Carrera de Medicina. Ambato, Ecuador

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Abstract

Introduction: Peyronie disease (PD) is an inflammatory and fibrotic disorder affecting the tunica albuginea of the penis that obeys a multifactorial approach. It is characterized by the formation of a plaque of fibrous tissue that produces an angular deformation of the penis, resulting in erectile dysfunction and psychosexual problems in the patient. Intralesional therapy was an option for a long time without convincing results until the implementation of Clostridium histolyticum collagenase (CCH).
Objective: To describe the clinical and psychological results of intralesional intervention with Clostridium histolyticum collagenase in the treatment of PD. Methods: We performed a literature search of updated information in the PubMed database using terms such as Peyronie's disease, penile fibromatosis, and collagenase clostridium histolyticum.
Results:15 investigations were obtained from 2018 to 2023, with a total of 2,844 patients, in all studies improvements in penile correction were reported, in 9 studies reported satisfactory results in IIEF-15 and PDQ, just as the results were influenced by individual characteristics, as well as the modification of the therapeutic protocol or aggregation of adjuvant therapies.
Conclusions: Intralesional therapy with CCH has been shown to be effective with and without the use of concomitant therapies in correcting penile curvature and decreasing psychosexual symptoms in PD from the first therapeutic cycle, as well as in atypical cases, acute stage, and in patients who reported calcification.

How to Cite

1.
Acosta Núñez C, Reyes Rosero EA. Clinical and psychological effects post intralesional management with Collagenase Clostridium histolyticum in Peyronie’s disease. Bibliographic review. Salud, Ciencia y Tecnología [Internet]. 2023 Jul. 2 [cited 2024 Apr. 22];3:419. Available from: https://revista.saludcyt.ar/ojs/index.php/sct/article/view/419

The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.

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