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Usefulness of lactate dehydrogenase as a predictor of mortality

By
Andy Gustavo Sánchez-Sánchez ,
Andy Gustavo Sánchez-Sánchez

Universidad Técnica de Ambato. Facultad de Ciencias de la Salud, Carrera de Laboratorio Clínico. Ambato, Ecuador

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Ana Gabriela Pacha Jara ,
Ana Gabriela Pacha Jara

Universidad Técnica de Ambato. Facultad de Ciencias de la Salud, Carrera de Laboratorio Clínico. Ambato, Ecuador

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Abstract

The enzyme lactate dehydrogenase, or LDH, is the final product of metabolism in all body cells. It can be detected once it passes into the extracellular space due to a pathological state such as tissue injury or necrosis. It is produced in different body organs under five different isoenzymatic forms LDH1, LDH2, LDH3, LDH4, and LDH5. A literature review was carried out to establish the validity of lactate dehydrogenase as a predictor of mortality through the correct measurement of this enzyme in the laboratory and, simultaneously, to provide information to health personnel on its proper interpretation. The standardized method allows the measurement of this enzyme; through the fundamental method of continuous monitoring, we measure the disappearance of NADH, for which two reagents are required, pyruvate and NADH.
Additionally, it is required that the pH is 7.4. The wavelength to be used for lactate dehydrogenase is 340nm. From 2020, LDH began to be used as an indicator of the development of severe disease and as a predictor of mortality in patients with covid-19, thanks to a proven relationship between elevated LDH levels and a worse prognosis in patients with this pathology. Although there are adverse factors that can modify LDH levels, this does not preclude using the enzyme as a predictor of mortality.

How to Cite

1.
Sánchez-Sánchez AG, Pacha Jara AG. Usefulness of lactate dehydrogenase as a predictor of mortality. Salud, Ciencia y Tecnología [Internet]. 2023 Jul. 15 [cited 2024 Jun. 20];3:437. Available from: https://revista.saludcyt.ar/ojs/index.php/sct/article/view/437

The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.

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